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Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)

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Introduction Neuropsychiatric disorders carry a significant burden and disproportionally affect more women than men (Wittchen et al., 2011)